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| Product Name | Anti-NLRP3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| WB:1:200-1:2000 IHC:1:200-1:1000 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1 mg/ml |
| Purification | Protein A |
| Gene Symbol | NLRP3 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | NLR family pyrin domain containing 3 |
| Gene Summary | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, ａnd a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, ａnd is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, ａnd it plays a role in the regulation of inflammation, the immune response, ａnd apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous ａnd articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, ａnd deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5＇ UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5＇ UTR splice patterns are biologically valid. [provided by RefSeq, Aug 2020] More |
| Molecular Weight(MW) | 118 kDa |
| Source | Rabbit |
| Cellular Localization | Cylasm; Endoplasmic reticulum; Golgi apparatus; Inflammasome; Membrane; Nucleus; Secreted |
Western blot analysis using NLRP3 antibody against A431 (1), A549 (2), Caco-2 (3), COS-7 (4) cell lysate.
Immunohistochemical analysis of paraffin-em
| Application Notes | WB:1:200-1:2000 IHC:1:200-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azi. |
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