標題BRCA1 antibody Catalog Number：OM241913

提供者：上海篤瑪生物科技有限公司發布時間：2024/8/23 閱讀次數：37次 >>進入該公司展臺

Product Name	BRCA1 antibody
Antibody Type	Primary Antibodies
Product description	Mouse Monoclonal Antibody [6C6D2] to BRCA1This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, ａnd it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the f More
Immunogen	The immunogen corresponding to a region within amino acids 229 ａnd 335 of human BRCA1 expressed in E. Coli.

Clonality	Monoclonal
Isotype	IgG1
Clone Number	6C6D2
Host Species	Mouse
Tested Applications	ELISAIHCIHC-PWB
	ELISA: 1/10000.:
Species Reactivity	Human
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration)
Purification

Gene Synonyms	IRIS PNCA4 BRCC1 PPP1R53 BROVCA1 PSCP BRCAI RNF53 More
Target	BRCA1
Molecular Weight(MW)	207.7 kDa (note)

Application

ELISA analysis of control antigen ａnd antigen using BRCA1 antibody [6C6D2].
Application

WB analysis of human BRCA1 recombinant protein using BRCA1 antibody [6C6D2].
Application

WB analysis of lysates from (1) untransfected ａnd (2) BRCA1 (a.a. 229-335)-hIgGFc transfected HEK293 cells using BRCA1 antibody [6C6D2].
Application

IHC-P analysis of esophagus cancer tissues using BRCA1 antibody [6C6D2].
Application

IHC-P analysis of esophagus tissues using BRCA1 antibody [6C6D2].

Application Notes	ELISA: 1/10000.:

Form	Liquid
Storage Instructions	4°C; -20°C for long term storage
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide ａnd 0.5% protein stabilizer.

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