標題IGF-I human

IGFs (insulin like growth factors) are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin ａnd relaxin.[1] The IGFs are similar by structure ａnd function to insulin, but have a much higher growth-promoting activity than insulin. IGF-I expression is regulated by growth hormone.[2] IGF-I signal through the tyrosine kinase type I receptor (IGF-IR).[3] Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal ａnd C-terminal propeptide regions.[4] Recombinant human IGF-I ａnd IGF-II are globular proteins containing 70 ａnd 67 amino acids, respectively, ａnd three intra-molecular disulfide bonds.

IGF-I human has been used:

• as positive control in the quantification of growth factors in adipose-derived stem cells using enzyme-linked immunosorbent assay (ELISA)[5]
• as a medium supplement for trunk crestosphere cultures[6]
• in stimulation protein kinase B (Akt) methylation in human embryonic kidney cells (HEK293) ａnd human melanoma cell line(A375)[7]

In broiler chicks, IGF-I human has been used to study the effect of fadrozole ａnd IGF-1 on female-to-male sex reversal ａnd body weight.[8]

The IGFs (insulin like growth factors) are mitogenic polypeptide growth factors that stimulate the proliferation ａnd survival of various cell types including muscle, bone, ａnd cartilage tissue in vitro.[9] IGF1 is an essential component for embryonic ａnd postnatal skeletal development. Absence of IGF1 in mice negatively affects bone development, causes hypomineralization of skeletons ａnd growth plate disturbances.[10] It is also associated with cancer progression. It can suppress cell death ａnd provides resistance to chemotherapy as well as radiation therapy.[11]

GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Lyophilized with no additives.

It is recommended to centrifuge the vial prior to reconstitution. A stock solution may be prepared by reconstituting in sterile 0.2% acetic acid (recommended) to a concentration of 1.0 mg/ml. The stock solution may be diluted further using aqueous buffers.