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HCXII-0155艾美捷人因子Ⅻ解決方案
點擊次數:0發布時間:2023/6/7 16:37:11
更新日期:2023/6/7 16:37:11
所 在 地:中國大陸
產品型號:
優質供應
詳細內容
XIIa的抑制劑包括 C1-INH、α2-抗纖溶酶、α2-巨球蛋白和抗凝血酶 III。在生理濃度下,這些抑制劑的相對有效性分別為 91 : 4.5 : 3 : 1.5。 C1-INH與XII的比例與因子VII的“冷激活”和血漿儲存過程中腎素原向腎素的轉化有關。人因子 XII是通過免疫親和層析從新鮮冷凍血漿中制備的,并以50%(體積/體積)甘油/水的形式提供,可在-20℃下儲存。
艾美捷人因子Ⅻ HCXII-0155相關參數:
Localization: 等離子
血漿濃度:40µg/ml(3)
作用方式:Zymogen;絲氨酸蛋白酶因子XIIa的體;
激肽釋放酶/HMWK/陰離子表面復合物激活
闡明內在途徑
分子量:80000(2)
消光系數:E1 cm,280 nm=14.0
等電點:6.8
結構:單鏈(Mr=80000),基于6個域組織
關于序列同源性(5)
碳水化合物百分比:17%
人因子Ⅻ HCXII-0155文獻參考:
1. Schmaier, A.H., et al., in Hemostasis and Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and
E.W. Salzman, pp 18-38, J.B. Lippincott Company, Philadelphia, 1987.
2. Griffin, J.H. and Cochrane, C.G., Methods Enzymol., 45, 56-65 (1976).
3. Saito, H., et al., J Lab Clin., 88, 506 (1976).
4. McMullen, B.A. and Fujikawa, N., J. Biol. Chem., 260, 5328 (1985).
5. Davie, E.W., in Hemostasis and Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and E.W.
Salzman, pp 242-267, J.B. Lippincott Company, Philadelphia, 1987.
6. Griffin, J.H., Proc. Natl. Acad. Sci. USA, 75, 1998 (1978).
7. McMillin, L.R., et al., J. Clin. Invest., 54, 1312 (1974).
8. Revak, S.D., et al., J. Clin. Invest., 59, 1167 (1977).
9. Fujikawa, K., et al., Biochemistry, 16, 4182 (1977).
10. Bonno, N., et al., in New Comprehensive Biochemistry, ed. R.F.A. Zwaal and H.C.Hemker,
pp. 103-128, Elsevier, Amsterdam, 1986.
11. Claeys, H. and Collen, D. (1978) Eur. J. Biochem., 87, 69 (1978).
12. Revak, S.D. and Cochrane, C.G., J. Clin. Invest., 57, 852 (1976).
13. Cochrane, C.G., et al., J. Exp. Med., 138, 1564 (1973).
14. Revak, S.D., et al., J. Exp. Med., 147, 719 (1978).
15. Ghebrehiwet, B., et al., J. Clin. Invest., 71, 1458 (1983).
16. DeAgostini, A., et al., J. Clin. Invest., 73, 1542 (1984).
17. Rathoff, O.D., et al., J. Exp. Med., 129, 315 (1969).
18. Stead, N., et al., J. Biol Chem., 251, 6481 (1976).
19. Pixley, R.A., et al., J. Biol Chem., 260, 1723 (1985).
20. Gjonnass, H., Thromb. Diath. Haemorrh., 28, 182 (1972).
21. Radcliffe, R., et al., Blood, 59, 611 (1977).