環巴胺對Hedgehog信號通路有抑制作用,在抗腫瘤方面表現出良好的活性。研究表明，環巴胺可以對Hedgehog信號通路的激活起到抑制作用，而后者參與原癌基因 Smoothened (Smo) 或滅活腫瘤抑制基因 Patched (Ptch) 的突變相關反應途徑，并且這兩種基因都能夠編碼多程跨膜蛋白。此外，已經證明環巴胺的抑制作用是由于其與Smo七螺旋蛋白束的直接結合有關。

艾美捷丨LC Laboratories 環巴胺 / Cyclopamine 目已經應用到quan球4100個實驗室，純度非常高，當然價格也是十分友好的。

環巴胺 / Cyclopamine 其它基本參數：

cat# LCL-C-8700

規格 10mg/25mg/100mg/300mg

CAS號 4449-51-8

分子式 C27H41NO2

分子量 411.62

純度 ＞99%

外觀 白色結晶固體；或小瓶底部透明固體膜

溶解性 溶于乙醇或DMSO

運輸與保存方法 常溫運輸；-20℃保存

Nature communications正文引用：

其他參考文獻

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[3]. Thayer SP, et al. Hedgehog is an early ａnd late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425(6960), 851-856.

[4]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits ａnd neuronal inflammation in animal models of Alzheimer＇s disease. J Genet Genomics. 2018 May 20;45(5):237-246.

[5]. Qi Wan, et al. Overexpression of Laminin α4 Facilitates Proliferation ａnd Migration of Fibroblasts in Knee Arthrofibrosis by Targeting Canonical Shh/Gli1 Signaling. Connect Tissue Res. 2020 May 24.