產品展示
Recombinant Murine IGF-1 Peprotech報價
點擊次數：38發布時間：2016/1/26 9:23:42
更新日期：2016/1/26 9:23:42
所 在 地：中國大陸
產品型號：250-19
優質供應
詳細內容
產品編號:
250-19
別名:
Insulin-like Growth Factor-I, Somatamedin C, IGF-IA
描述:
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation ａnd survival of various cell types, including muscle, bone, ａnd cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin ａnd relaxin. The IGFs are similar to insulin by structure ａnd function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I ａnd IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal ａnd C-terminal propeptide regions. Recombinant Murine IGF-I is a 7.6 kDa globular protein containing amino acids including 3 intra-molecular disulfide bonds.
氨基酸序列:
GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA
來源:
E.coli
純度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 was determined a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
交叉反應:
Rat, Mouse
研究領域:
原產國:
USA
僅用于研究。不適用于診斷或治療。
