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【別    名】Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Beta Lipotropin; Beta Melanocyte Stimulating Hormone; CLIP; Corticotropin; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin precursor; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Met Enkephalin; MSH; NPP; POC; POMC; Pro opiomelanocortin; Proopiomelanocortin; COLI_HUMAN.

【規   格】0.1ml：0.2ml    

【研究域】腫瘤  神經生物學  信號轉導  生長因子和激素  內分泌病  

【抗體來源】Rabbit

【克隆類型】Polyclonal

【交叉反應】Human, 

【產品應用】ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.
促腎上腺皮質激素ACTH(18-39)抗體

【分 子 量】2.5/4.5kDa

【性    狀】凍干或液體

【濃    度】1mg/1ml

【免 疫 原】KLH conjugated synthetic peptide derived from human ACTH(18-39)

【亞    型】IgG

【純化方法】親和純化的蛋白

【儲 存 液】儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.

【篤瑪 貯   存說明】-20°C的一年。避免重復凍結/解凍周期。凍干抗體穩定在室溫下至少一個月,超過一年保持在-20°C。重組在無菌pH值7.4 - 0.01 m PBS或稀釋的抗體抗體穩定至少兩周2 - 4°C。

促腎上腺皮質激素ACTH(18-39)抗體產品介紹  

background:

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type ａnd the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis ａnd the maintenance of normal adrenal weight, ａnd lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, ａnd epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain ａnd energy homeostasis, melanocyte stimulation, ａnd immune modulation. These include several distinct melanotropins, lipotropins, ａnd endorphins that are contained within the adrenocorticotrophin ａnd beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, ａnd red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

 

Function:

ACTH stimulates the adrenal glands to release cortisol. 

MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. 

Beta-endorphin ａnd Met-enkephalin are endogenous opiates. 

 

Subcellular Location:

Secreted.

 

Tissue Specificity:

ACTH ａnd MSH are produced by the pituitary gland.

 

Post-translational modifications:

Specific enzymatic cleavages at paired basic residues yield the different active peptides. 

O-glycosylated; reducing sugar is probably N-acetylgalactosamine. 

 

DISEASE:

Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal ａnd physical requirements, as the result of excessive accumulation of body fat. 

Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency ａnd red hair. 

 

Similarity:

Belongs to the POMC family.

 

 

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