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              技術文章

              DLGAP1 antibody Catalog Number:OM250145

              點擊次數:38 發布時間:2024/9/29 14:54:34
               

              Product Profile

              Product Name DLGAP1 antibody
              Antibody Type Primary Antibodies
              Product description
              Rabbit polyclonal antibody to DLGAP1SAP90/PSD-95-associated protein 1 (SAPAP1, also known as DLGAP1 or GKAP) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM). At least three isoforms of SAPAP1 are known to exist. This SAPAP1 antibody will not cross-react with other SAPAP proteins.
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              Key Feature

              Clonality Polyclonal
              Host Species Rabbit
              Tested Applications

              ELISAICC/IFIHC-PWB

               
              ICC/IF:1:200~1:500
              IHC-P:1:50~1:200
              WB:1:500~1:2000
              Notes:Optimal dilutions/concentrations should be determined by the researcher.
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              Species Reactivity

              Human

              Concentration 1 mg/ml
              Purification Affinity purified

              Target Information

              Gene Synonyms
              Disks largeassociated protein1
              DAP1
              DAP-1
              Disks large-associated protein 1
              SAP90/PSD-95-associated protein 1
              Disks largeassociated protein 1
              SAPAP1
              SAP90/PSD95associated protein 1
              GKAP
              SAP90/PSD95associated protein1
              DLGAP1
              DAP 1
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              Target DLGAP1
              Tissue Specificity This antibody is specific for DLGAP1

              Application

              • Application

                Immunohistochemistry of SAPAP1 in human brain with SAPAP1 antibody at 5 ug/ml.

              • Application

                Immunofluorescence of SAPAP1 in Human Brain cells with SAPAP1 antibody at 20 ug/mL.

              • Application

                Western blot analysis of SAPAP1 in human brain tissue lysate with SAPAP1 antibody at (A) 0.5 and (B) 1 ug/ml.

              Positive Control Blocking Peptide:
              Application Notes
              ICC/IF:1:200~1:500
              IHC-P:1:50~1:200
              WB:1:500~1:2000
              Notes:Optimal dilutions/concentrations should be determined by the researcher.
              More 

              Additional Information

              Form Liquid
              Storage Instructions Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
              Storage Buffer PBS containing 0.02% sodium azide
               

              原創作者:上海篤瑪生物科技有限公司

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