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技術文章
Rabbit anti-MCM7 polyclonal antibody - middle region Catalog Number：OM107936
點擊次數：42 發布時間：2024/9/27 14:56:40
Product Profile
| Product Name | Rabbit anti-MCM7 polyclonal antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-MCM7 antibody: synthetic peptide directed towards the middle region of human MCM7 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | BovineHumanRabbitRat |
| Concentration | 1 mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | MCM7 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | Minichromosome maintenance complex component 7 |
| Gene Summary | MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) ａnd may be involved in the formation of replication forks ａnd in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein ａnd MCM2, 4 ａnd 6 proteins possesses DNA helicase activity, ａnd may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) ａnd may be involved in the formation of replication forks ａnd in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein ａnd MCM2, 4 ａnd 6 proteins possesses DNA helicase activity, ａnd may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, ａnd may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. More |
| Alternative Names | More |
| Molecular Weight(MW) | 81kDa |
| Sequence | 719 amino acids |
Database Links
| Entrez Gene | 4176 |
|---|---|
| SwissProt ID | P33993 |
| Protein Accession | NP_005907 |
Application
-
Western blot
1.25ug/ml
Positive Control: Daudi cell lysate -
Immunohistochemical
| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot ａnd store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
原創作者：上海篤瑪生物科技有限公司
