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              技術文章

              Myelin basic protein antibody Catalog Number:OM264370

              點擊次數:40 發布時間:2024/9/25 15:06:05
               

              Product Profile

              Product Name Myelin basic protein antibody
              Antibody Type Primary Antibodies
              Product description
              Rabbit polyclonal to Myelin Basic Protein - Oligodendrocyte MarkerThe classic group of Myelin basic protein (MBP) isoforms (isoforms 4-14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoforms 1-3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
              More 
              Immunogen
              Human myelin basic protein isolated from normal human brain.

              Key Feature

              Clonality Polyclonal
              Host Species Rabbit
              Tested Applications

              IHCIHC-P

               
              For IHC-P: Use at a dilution of 1:50-1:100 in an ABC method. We suggest an incubation period of 30 minutes at RT. Optimal dilutions/concentrations should be determined by the researcher.:
              Species Reactivity

              Human

              Concentration 1 mg/ml
              Purification Affinity purified

              Target Information

              Gene Synonyms
              4155
              Myelin basic protein
              MBP
              MGC99675
              P02686
              159430
              More 
              Target Myelin basic protein
              Tissue Specificity This antibody reacts with human myelin basic protein and oligodendrocytes of white matter in brain and spinal cord. Grey matter stains weakly. This antibody also stains peripheral nerves.
              Cellular Localization Cylasmic side of myelin

              Application

              • Application

                Formalin fixed paraffin embedded human brain stained with MBP antibody .

              • Application

                at a dilution of 1/1000, staining Myelin Basic Protein (MBP; Alexa 488 secondary at 1/2000) in the cortex of rat brain tissue (30m thick coronal sections). Staining was obtained following free floating IHC (see protocol link for detailed descript

              • Application

                at a dilution of 1/1000, staining Myelin Basic Protein (MBP; Alexa 488 secondary at 1/2000) in the cortex and hippocampus of rat brain tissue (30m thick coronal sections). Staining was obtained following free floating IHC (see protocol link for d

              • Application

                Detection of Myelin basic protein by IHC in Human Breast

              Positive Control Brain
              Application Notes
              For IHC-P: Use at a dilution of 1:50-1:100 in an ABC method. We suggest an incubation period of 30 minutes at RT. Optimal dilutions/concentrations should be determined by the researcher.:

              Additional Information

              Form Liquid
              Storage Instructions Keep as concentrated solution, aliquot and store at 4°C.
              Storage Buffer Contains sodium azide

              原創作者:上海篤瑪生物科技有限公司

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