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              技術文章

              Phospho-MAPK8-pT183 Antibody Catalog Number:OM217490

              點擊次數:31 發布時間:2024/9/12 15:17:58
               

              Product Profile

              Product Name Phospho-MAPK8-pT183 Antibody
              Antibody Type Primary Antibodies

              Key Feature

              Clonality Polyclonal
              Isotype Ig
              Host Species Rabbit
              Tested Applications

              DB

               
              DB~~1:500:
              Species Reactivity

              Human

              Concentration 1 mg/ml
              Purification  

              Target Information

              Gene Synonyms
              JNK1
              PRKM8
              SAPK1
              SAPK1C
              More 
              Alternative Names
              MAPK8
              JNK1
              PRKM8
              SAPK1
              SAPK1C
              Mitogen-activated protein kinase 8
              JNK-46
              Stress-activated protein kinase 1c
              Stress-activated protein kinase JNK1
              c-Jun N-terminal kinase 1
              More 
              Molecular Weight(MW) 48296 Da
              Function
              Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1 In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of auhagy Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cylasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH
              More 
              Tissue Specificity This Phospho-MAPK8-pT183 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T183 of human MAPK8.
              Cellular Localization Cylasm. Nucleus.

              Database Links

              Entrez Gene 5599

              Application

              • Application

                Dot blot analysis of anti-MAPK8-pT183 Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

              Application Notes
              DB~~1:500:

              Additional Information

              Form Liquid
              Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
              Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein A affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

              原創作者:上海篤瑪生物科技有限公司

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