The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, ａnd are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation ａnd development. This kinase is activated by various cell stimuli, ａnd targets specific transcription factors, ａnd thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis ａnd differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.1) Dasgupta, J., et al. J. Cell. Physiol. 225(1):52-62(2010)
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This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-195 amino acids from human MAPK8.

IHC-PWB

Human