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              技術文章

              PPM1A antibody Catalog Number:OM269346

              點擊次數:38 發布時間:2024/9/11 14:02:19
               

              Product Profile

              Product Name PPM1A antibody
              Antibody Type Primary Antibodies
              Product description
              Rabbit Polyclonal antibody to PPM1A (protein phosphatase, Mg2+/Mn2+ dependent, 1A)The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
              More 
              Immunogen
              Recombinant protein encompassing a sequence within the center region of human PPM1A. The exact sequence is proprietary.

              Key Feature

              Clonality Polyclonal
              Isotype IgG
              Host Species Rabbit
              Tested Applications

              ICC/IFIHC-PWB

               
              *Optimal dilutions/concentrations should be determined by the researcher. :
              Species Reactivity

              HumanMouseRat

              Predicted Reactivity Rabbit, BovineRabbit (86%), Bovine (92%)
              Concentration 1 mg/ml (Please refer to the vial label for the specific concentration)
              Purification Affinity purified

              Target Information

              Gene Synonyms
              FLJ42306 antibody
              MGC9201 antibody
              PP2C-ALPHA antibody
              PP2CA antibody
              PP2Calpha antibody
              PPM1A antibody
              protein phosphatase 1A (formerly 2C)
              magnesium-dependent
              alpha isoform antibody
              protein phosphatase 1A antibody
              protein phosphatase
              Mg2+/Mn2+
              More 
              Molecular Weight(MW) 42 kDa (note)

              Application

              • Application

                PPM1A antibody detects PPM1A protein at cylasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PPM1A protein stained by PPM1A antibody diluted at 1:500. Blue: Hoechst 33342 staining.

              • Application

                Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using PPM1A antibody at 1:500 dilution.

              • Application

                Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE diluted at 1:10000

              • Application

                Sample (30 ug of whole cell lysate) A: Raji 10% SDS PAGE diluted at 1:1000

              • Application

                Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with PPM1A antibody diluted at 1:500.

              Positive Control Raji , mouse brain , PC-12 , Rat2
              Application Notes
              *Optimal dilutions/concentrations should be determined by the researcher. :

              Additional Information

              Form Liquid
              Storage Instructions Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
              Storage Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

              原創作者:上海篤瑪生物科技有限公司

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