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              技術文章

              PPM1A Antibody Catalog Number:OM288632

              點擊次數:28 發布時間:2024/9/11 13:59:00
               

              Product Profile

              Product Name PPM1A Antibody
              Antibody Type Primary Antibodies
              Product description
              The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
              More 
              Immunogen
              This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-382 amino acids from human PPM1A.

              Key Feature

              Clonality Polyclonal
              Isotype Ig
              Host Species Rabbit
              Tested Applications

              WB

               
              For WB starting dilution is: 1:1000:
              Species Reactivity

              Human

              Concentration 1 mg/ml
              Purification Affinity purified

              Target Information

              Gene Symbol PPM1A
              Alternative Names
              Protein phosphatase 1A
              Protein phosphatase 2C isoform alpha
              PP2C-alpha
              Protein phosphatase IA
              PPM1A
              PPPM1A
              More 
              Molecular Weight(MW) 42 kDa
              Sequence Similarities Predicted species reactivity based on immunogen sequence: Bovine

              Database Links

              Entrez Gene 5494
              Protein Accession P35813

              Application

              • Application

                Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstratesdetected the PPM1A protein (arrow).

              Application Notes
              For WB starting dilution is: 1:1000:

              Additional Information

              Form Liquid
              Storage Instructions Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
              Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.

              原創作者:上海篤瑪生物科技有限公司

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