Rabbit Polyclonal antibody to GluR2Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain ａnd are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), ａnd function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human ａnd animal studies suggest that pre-mRNA editing is essential for brain function, ａnd defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip ａnd flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
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A synthetic peptide corresponding to a N-terminal region of Human GluR2.

IHC-F

Mouse