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技術文章
Anti-GluR2 antibody Catalog Number：OM642190
點擊次數：30 發布時間：2024/9/11 13:48:27
Product Profile
| Product Name | Anti-GluR2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IF |
| ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1 mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | GRIA2 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | glutamate ionotropic receptor AMPA type subunit 2 |
| Gene Summary | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain ａnd are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), ａnd function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human ａnd animal studies suggest that pre-mRNA editing is essential for brain function, ａnd defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip ａnd flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] More |
| Cellular Localization | Cell membrane, postsynaptic cell membrane, postsynaptic density membrane, endoplasmic reticulum membrane |
Application
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ICC/IF
Immunofluorescence analysis of Hela cells using GluR2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | ICC/IF:1:100-1:500 |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
原創作者：上海篤瑪生物科技有限公司
