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              技術文章

              GluR2/3 Antibody Catalog Number:OM279912

              點擊次數:20 發布時間:2024/9/11 13:42:26
               

              Product Profile

              Product Name GluR2/3 Antibody
              Antibody Type Primary Antibodies
              Product description
              The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003; Seidenman et al., 2003; Chung et al., 2003; Yan et al., 2002).1) Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.
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              Immunogen
              Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3

              Key Feature

              Clonality Polyclonal
              Host Species Rabbit
              Tested Applications

              WB

               
              The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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              Species Reactivity

              ChickenHumanMouseRatZebra Fish

              Concentration 1 mg/ml
              Purification Affinity purified

              Target Information

              Gene Symbol Gria2
              Alternative Names
              GluA2
              GluR2
              gluR-B
              GluR-K2
              Glur2
              AMPA-selective glutamate receptor 2
              GluR-2
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              Molecular Weight(MW) 100

              Database Links

              Entrez Gene 29627
              Protein Accession P19491

              Application

              • Application

                Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein.

              Application Notes
              The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
              More 

              Additional Information

              Form Liquid
              Storage Instructions GluR2/3 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
              Storage Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
               

              原創作者:上海篤瑪生物科技有限公司

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