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              技術文章

              GRIA2 [A3-A7] Catalog Number:OM627371

              點擊次數:20 發布時間:2024/9/11 13:36:31
               

              Product Profile

              Product Name GRIA2 [A3-A7]
              Antibody Type Primary Antibodies
              Product description
              Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
              More 
              Immunogen
              Recombinant protein

              Key Feature

              Clonality Monoclonal
              Isotype IgG2b
              Host Species Mouse
              Tested Applications

              WBIHCFC

               
              WB:1:500-1:2,000
              IHC:1:50-1:200
              FC:1:50-1:100
              Species Reactivity

              Human

              Concentration 2 mg/mL.

              Target Information

              Alternative Names
              AMPA 2 antibody AMPA selective glutamate receptor 2 antibody AMPA-selective glutamate receptor 2 antibody AMPA2 antibody GluA2 antibody GLUR 2 antibody GLUR B antibody GluR K2 antibody GluR-2 antibody GluR-B antibody GluR-K2 antibody GLUR2 antibody GLURB antibody Glutamate receptor 2 antibody Glutamate receptor ionotropic AMPA 2 antibody Glutamate receptor ionotropic antibody Gria2 antibody GRIA2_HUMAN antibody HBGR2 antibody
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              Molecular Weight(MW) 99 kDa
              Cellular Localization Cell membrane. Endoplasmic reticulum membrane

              Database Links

              SwissProt ID P42262

              Application

              • Application

                Fig1: Western blot analysis of Glutamate receptor 2 on human GRIA2 recombinant protein using anti- Glutamate receptor 2 antibody at 1/1,000 dilution.

              • Application

                Fig2: Western blot analysis of Glutamate receptor 2 on HEK293 (1) and Glutamate receptor 2-hIgGFc transfected HEK293 (2) cell lysate using anti- Glutamate receptor 2 antibody at 1/1,000 dilution.

              • Application

                Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using anti- Glutamate receptor 2 antibody. Counter stained with hematoxylin.

              • Application

                Fig4: Flow cytometric analysis of SK-N-SH cells with Glutamate receptor 2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

              Positive Control Human Glutamate receptor 2 recombinant protein, Glutamate receptor 2-hIgGFc transfected HEK293 cell lysate, human rectum cancer tissues, SK-N-SH.
              Application Notes
              WB:1:500-1:2,000
              IHC:1:50-1:200
              FC:1:50-1:100

              Additional Information

              Form Liquid
              Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
              Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

              原創作者:上海篤瑪生物科技有限公司

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