Rabbit Polyclonal antibody to INCENPIn mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins ａnd ＇passenger,＇ or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), ａnd CENPD (MIM 117142). The term ＇passenger proteins＇ encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw ａnd Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cylasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); ａnd CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw ａnd Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
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KLH-conjugated synthetic peptide encompassing a sequence within the center region of human INCENP. The exact sequence is proprietary.

WB

HumanMouseRat