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技術文章
Csnk2a2 Antibody (N-term) Catalog Number：OM214088
點擊次數：24 發布時間：2024/9/9 14:09:14
Product Profile
| Product Name | Csnk2a2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB~~1:100~500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Alternative Names | |
|---|---|
| Molecular Weight(MW) | 41215 Da |
| Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis ａnd transcription, as well as viral infection. May act as a regulatory node which integrates ａnd coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity ａnd G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating ＇Ser-392＇ of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis Phosphorylates the caspases CASP9 ａnd CASP2 ａnd the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage ａnd activation by CASP8, ａnd inhibits the dimerization of CASP2 ａnd activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III ａnd IV. Also phosphorylates ａnd regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC ａnd MYB. Phosphorylates Hsp90 ａnd its co-chaperones FKBP4 ａnd CDC37, which is essential for chaperone function Regulates Wnt signaling by phosphorylating CTNNB1 ａnd the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity) More |
| Tissue Specificity | This Mouse Csnk2a2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of Mouse Csnk2a2. |
Database Links
| Entrez Gene | 13000 |
|---|---|
| Nucleotide Accession | NP_034104.1 |
Application
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Application
Mouse Csnk2a2 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the Csnk2a2 antibody detected the Csnk2a2 protein (arrow).
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Application
Mouse Csnk2a2 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Csnk2a2 antibody detected the Csnk2a2 protein (arrow).
| Application Notes | WB~~1:100~500: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
原創作者：上海篤瑪生物科技有限公司
