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              技術文章

              CD59 antibody Catalog Number:OM245692

              點擊次數:32 發布時間:2024/9/4 14:42:15
               

              Product Profile

              Product Name CD59 antibody
              Antibody Type Primary Antibodies
              Product description
              Rabbit Polyclonal antibody to CD59 (CD59 molecule, complement regulatory protein)This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]
              More 
              Immunogen
              Recombinant protein encompassing a sequence within the center region of human CD59. The exact sequence is proprietary.

              Key Feature

              Clonality Polyclonal
              Isotype IgG
              Host Species Rabbit
              Tested Applications

              IHC-PWB

               
              *Optimal dilutions/concentrations should be determined by the researcher. :
              Species Reactivity

              Human

              Predicted Reactivity ChimpanzeeChimpanzee (96%)
              Concentration 1 mg/ml
              Purification Affinity purified

              Target Information

              Gene Synonyms
              MEM43
              MIC11
              EJ30
              p18-20
              MIN2
              MSK21
              16.3A5
              MAC-IP
              HRF-20
              EL32
              MACIF
              MIN1
              1F5
              CD59 molecule
              complement regulatory protein
              EJ16
              MIRL
              MIN3
              G344
              HRF20
              More 
              Target CD59
              Molecular Weight(MW) 14 kDa (note) (8)
              Cellular Localization Cell membrane , GPI-anchor , Secreted

              Application

              • Application

                CD59 antibody detects CD59 protein at cell membrane in human cervical carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human colon carcinoma. CD59 antibody diluted at 1:500.

              • Application

                CD59 antibody detects CD59 protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with CD59 antibody diluted at 1:1000.

              Positive Control K562 , HL-60
              Application Notes
              *Optimal dilutions/concentrations should be determined by the researcher. :

              Additional Information

              Form Liquid
              Storage Instructions Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
              Storage Buffer 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

              原創作者:上海篤瑪生物科技有限公司

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