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技術文章
Anti-CD59 antibody Catalog Number：OM642651
點擊次數：33 發布時間：2024/9/4 14:40:47
Product Profile
| Product Name | Anti-CD59 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFWB |
| WB:1:200-1:2000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | CD59 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | CD59 molecule (CD59 blood group) |
| Gene Summary | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, ａnd it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia ａnd thrombosis, ａnd which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] More |
| Molecular Weight(MW) | 14KD |
| Cellular Localization | Cell membrane, Membrane, Secreted |
Application
-
WB
Western blot analysis using CD59 antibody against Hek293(1) cell lysate.
-
ICC/IF
Immunofluorescence analysis of Hela cells using CD59 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:200-1:2000 ICC/IF:1:100-1:500 |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
原創作者：上海篤瑪生物科技有限公司
