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              技術文章

              CD59 Antibody Catalog Number:OM274790

              點擊次數:33 發布時間:2024/9/4 14:02:43
               

              Product Profile

              Product Name CD59 Antibody
              Antibody Type Primary Antibodies
              Product description
              CD59 Antibody: The complement regulatory protein CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and ultimately cerebral infarction.1) Venneker GT and Asghar SS. CD59: a molecule involved in antigen presentation as well as downregulation of membrane attack complex. Exp. Clin. Immunogenet. 1992; 9:33-47.
              More 
              Immunogen
              Rabbit polyclonal CD59 antibody was raised against a 14 amino acid peptide near the amino terminus of human CD59. The immunogen is located within the first 50 amino acids of CD59.

              Key Feature

              Clonality Polyclonal
              Isotype IgG
              Host Species Rabbit
              Tested Applications

              ELISAWB

               
              CD59 antibody can be used for detection of CD59 by Western blot at 1 - 2 μg/mL.:
              Species Reactivity

              HumanMouse

              Concentration 1 mg/ml
              Purification Affinity purified

              Target Information

              Gene Symbol CD59
              Alternative Names
              CD59 Antibody: 1F5
              EJ16
              EJ30
              EL32
              G344
              MIN1
              MIN2
              MIN3
              MIRL
              HRF20
              MACIF
              MEM43
              MIC11
              MSK21
              16.3A5
              HRF-20
              MAC-IP
              p18-20
              CD59 glycoprotein
              1F5 antigen
              More 
              Molecular Weight(MW) 14 kDa
              Sequence Similarities Predicted species reactivity based on immunogen sequence: Pig: (86%)

              Database Links

              Entrez Gene 966
              Protein Accession NP_000602

              Application

              • Application

                Western blot analysis of CD59 in mouse spleen tissue lysate with CD59 antibody at 1 μg/mL

              Positive Control 1) Cat. No. 1406 - Mouse Spleen Tissue Lysate
              Application Notes
              CD59 antibody can be used for detection of CD59 by Western blot at 1 - 2 μg/mL.:

              Additional Information

              Form Liquid
              Storage Instructions CD59 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
              Storage Buffer CD59 Antibody is supplied in PBS containing 0.02% sodium azide.
               

              原創作者:上海篤瑪生物科技有限公司

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