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聯系人：楊燕燕
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技術文章
DKK3 Antibody (N-term) Catalog Number：OM231334
Product Profile
| Product Name | DKK3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC~~1:50~100 WB~~1:100~500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Gene Synonyms | |
|---|---|
| Alternative Names | |
| Molecular Weight(MW) | 38390 Da |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt ａnd by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis ａnd eye formation. In the adult, Dkks are implicated in bone formation ａnd bone disease, cancer ａnd Alzheimer disease (By similarity) More |
| Tissue Specificity | Highest expression in heart, brain, ａnd spinal cord |
| Cellular Localization | Secreted. |
Database Links
| Entrez Gene | 27122 |
|---|---|
| Nucleotide Accession | NP_037385 |
Application
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Application
Formalin-fixed ａnd paraffin-embedded human brain tissue reacted with DKK3 antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
-
Application
Formalin-fixed ａnd paraffin-embedded human breast carcinoma tissue reacted with DKK3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Application
DKK3 Antibody (A30) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DKK3 antibody detected the DKK3 protein (arrow).
| Application Notes | IHC~~1:50~100 WB~~1:100~500: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high ａnd low pH buffers ａnd neutralized immediately, followed by dialysis against PBS. |
原創作者：上海篤瑪生物科技有限公司
