企業檔案
- 會員類型：免費會員
- 工商認證： 【已認證】
- 最后認證時間：
- 法人：
- 注冊號：
- 企業類型：生產商
- 注冊資金：人民幣萬
聯系我們
聯系人：楊燕燕
技術文章
Flt3 Antibody (N-term) Catalog Number：OM214140
點擊次數：30 發布時間：2024/8/26 14:29:44
Product Profile
| Product Name | Flt3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB~~1:100~500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Gene Synonyms | |
|---|---|
| Alternative Names | More |
| Molecular Weight(MW) | 112640 Da |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG ａnd regulates differentiation, proliferation ａnd survival of hemaoietic progenitor cells ａnd of dendritic cells. Promotes phosphorylation of SHC1 ａnd AKT1, ａnd activation of the downstream effector MTOR. Promotes activation of RAS signaling ａnd phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, ａnd STAT5A and/or STAT5B Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation ａnd resistance to apoptosis via the activation of multiple signaling pathways More |
| Tissue Specificity | Hemaoietic stem ａnd progenitor cell- enriched populations. Found in brain, placenta ａnd testis |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen (By similarity) Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface ａnd a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity) |
Database Links
| Entrez Gene | 14255 |
|---|---|
| Nucleotide Accession | NP_034359.2 |
Application
-
Application
Mouse Flt3 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Flt3 antibody detected the Flt3 protein (arrow).
| Application Notes | WB~~1:100~500: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
原創作者：上海篤瑪生物科技有限公司
