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              聯系人:楊燕燕

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              技術文章

              FLT3 [C3-B7] Catalog Number:OM627668

              點擊次數:19 發布時間:2024/8/26 14:24:36
                

              Product Profile

              Product Name FLT3 [C3-B7]
              Antibody Type Primary Antibodies
              Product description
              Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hemaoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
              More 
              Immunogen
              Recombinant protein

              Key Feature

              Clonality Monoclonal
              Isotype IgG1
              Host Species Mouse
              Tested Applications

              WBIHC

               
              WB:1:250~1:1000
              IHC:1:20~1:100
              Notes:Optimal dilutions/concentrations should be determined by the researcher.
              Species Reactivity

              Human

              Concentration 2 mg/mL.

              Target Information

              Alternative Names
              CD 135 antibody CD135 antibody CD135 antigen antibody Fetal liver kinase 2 antibody FL cytokine receptor antibody Flk 2 antibody Flk2 antibody Flt 3 antibody FLT-3 antibody Flt3 antibody FLT3_HUMAN antibody FMS like tyrosine kinase 3 antibody Fms related tyrosine kinase 3 antibody Fms-like tyrosine kinase 3 antibody Growth factor receptor tyrosine kinase type III antibody Ly-72 antibody OTTHUMP0000004234 antibody Receptor type tyrosine protein kinase FLT3 antibody Stem cell tyrosine kinase 1 antibody Stk 1 antibody STK-1 antibody Stk1 antibody Tyrosine protein kinase receptor FLT3 antibody Tyrosine-protein kinase receptor FLT3 antibody
              More 
              Molecular Weight(MW) 113 kDa
              Cellular Localization Endoplasmic reticulum lumen, membrane.

              Database Links

              SwissProt ID P36888

              Application

              • Application

                Fig1: Western blot analysis of FLT3 on human FLT3 recombinant protein using anti-FLT3 antibody at 1/1,000 dilution.

              • Application

                Fig2: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-FLT3 antibody. Counter stained with hematoxylin.

              • Application

                Fig3: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-FLT3 antibody. Counter stained with hematoxylin.

              Positive Control Human FLT3 recombinant protein, FLT3-hIgGFc transfected HEK293 cell lysate, human cervical cancer tissue. human liver cancer tissue.
              Application Notes
              WB:1:250~1:1000
              IHC:1:20~1:100
              Notes:Optimal dilutions/concentrations should be determined by the researcher.

              Additional Information

              Form Liquid
              Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
              Storage Buffer 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
               

              原創作者:上海篤瑪生物科技有限公司

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