Rabbit polyclonal antibody to BRCA1 (phospho Ser1423)This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, ａnd it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the f
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The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1423.

IHC-PWB

Human