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技術文章
消息：硫酸葡聚糖 鈉鹽 來源于明串珠菌 屬@2024資料文獻已更新
別名:6-O-(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-D-glucose, Manninotriose
CAS號:9011-18-1
MDL編號:MFCD00081551
NACRES:NA.31
生物來源
synthetic
等
for molecular biology
形式
powder
分子量
average Mw >500,000 (dextran starting material)
包含
0.5-2% phosphate buffer
組成
Sulfur Content, 16.0-19.0%
technique(s)
FISH: suitable
FTIR: suitable
顏色
off-white
useful pH range
6.0-8 (10 g/L)
溶解性
H2O: 100 mg/mL
適用性
suitable for marker for electrophoresis
suitable for nucleic acid hybridization
application(s)
genomic analysis
sample preparation
儲存溫度
2-8°C
一般描述
Dextran sulfate sodium (DSS) is a synthetic sulfated derivative of dextran, a complex polysaccharide composed of glucose molecules. DSS is characterized as a biocompatible, highly branched polysaccharide with 1–6 ａnd 1–4 glycosidic linkages, featuring approximately 2.3 sulfate groups per glucosyl unit. Dextran sulfate is a sulfated polysaccharide with a variable molecular weight ranging from 5 to 1,400 kDa. It finds extensive use in molecular biology ａnd biochemical research, with a particular emphasis on gastrointestinal investigations.DSS is widely recognized for its ability to induce colonic inflammation in mouse models of inflammatory bowel disease (IBD). It is widely recognized for its capacity to induce colonic inflammation in mouse models of inflammatory bowel disease (IBD) by creating models of acute, chronic, ａnd relapsing IBD, by adjusting its concentration ａnd administration frequency. Furthermore, Dextran sulfate is applied in various molecular biology techniques, such as precipitating lipoproteins, accelerating DNA probe hybridization, ａnd facilitating ribosomal isolations. Notably, DSS serves as a valuable cross-linker for chitosan, allowing for the creation of microparticles ａnd nanoparticles used in controlled drug delivery systems. Beyond these applications, DSS plays a central role in diverse research areas, particularly immunology ａnd virology, where it actively modulates immune responses, enhances humoral immunity, influences B-lymphocyte activation, ａnd affects thymocyte reactivity to lectins.
消息：硫酸葡聚糖 鈉鹽 來源于明串珠菌 屬@2024資料文獻已更新
應用
葡聚糖硫酸酯具有許多用途，當進行核酸雜交時可用作縮短探針退火所需時間的促進劑。當雜交速率成為檢測稀有序列的限制因子時或當可用探針數量有，可在雜交緩沖液中加入葡聚糖硫酸酯。葡聚糖硫酸酯通過從聚合物所占溶液體積中扣除核酸而發揮促進劑的作用，從而提高有效的探針濃度。
Dextran sulfate has been used
as a molecular weight marker to assess the purity ａnd homogeneity of the purified polysaccharides by gel electrophoresis[1]
as a component of the hybridization buffer in fluorescence in situ hybridization (FISH) protocol for DNA detection ａnd analysis[2][3]
生化/生理作用
Dextran sulfate, being a sulfated polysaccharide, consistently triggers experimental acute ａnd chronic colitis. It is believed to initiate mucosal injury ａnd inflammation, primarily through a direct toxic impact on epithelial cells. This initial effect activates macrophages ａnd T lymphocytes, ultimately leading to cytokine-mediated cytotoxicity.
特點和優勢
Suitable for Nucleic acid hybridization & Molecular Biology
Dextran Sulfate with an average molecular weight of >500,000
Sulfur Content of 16.0-19.0 %
Versatile ａnd adaptable for wide variety of laboratory ａnd research applications
適用性
已測試了在核酸雜交中的適應性
其他說明
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
IF<5，贈送價值 500元禮品卡
5 ≤IF≤10，贈送價值 1000元禮品卡
IF≥10，贈送價值 1000元禮品卡+任意 1 款 ValukineTM 試劑盒
DUMABIO ELISA試劑盒文獻征集獎勵活動
為感謝各位老師對篤瑪品牌的支持與厚愛，凡購買DUMABIO ELISA試劑盒，在SCI期刊雜志發表文中注明ELISA試劑盒采購上海篤瑪生物科技有限公司（Shanghai DuMa Biotechnology Co., Ltd.）
Shanghai DuMa Biotechnology Co., Ltd.
發表刊物 影響因子 獎勵金額
SCI期刊雜志 1.0≤1F＜3.0 200元
SCI期刊雜志 3.0≤1F＜6.0 400元
SCI期刊雜志 6.0≤1F＜10.0 600元
SCI期刊雜志 1F≥10 1000元
原創作者：上海篤瑪生物科技有限公司
