XIIa的抑制劑包括 C1-INH、α2-抗纖溶酶、α2-巨球蛋白和抗凝血酶 III。在生理濃度下，這些抑制劑的相對有效性分別為 91 : 4.5 : 3 : 1.5。 C1-INH與XII的比例與因子VII的“冷激活”和血漿儲存過程中腎素原向腎素的轉化有關。人因子 XII是通過免疫親和層析從新鮮冷凍血漿中制備的，并以50%（體積/體積）甘油/水的形式提供，可在-20℃下儲存。

艾美捷人因子Ⅻ HCXII-0155相關參數：

Localization: 等離子

血漿濃度：40µg/ml（3）

作用方式：Zymogen；絲氨酸蛋白酶因子XIIa的體；

激肽釋放酶/HMWK/陰離子表面復合物激活

闡明內在途徑

分子量：80000（2）

消光系數：E1 cm，280 nm=14.0

等電點：6.8

結構：單鏈（Mr=80000），基于6個域組織

關于序列同源性（5）

碳水化合物百分比：17%

Localization: Plasma

Plasma concentration: 40 µg/ml (3)

Mode of action: Zymogen; precursor to the serine protease factor XIIa;

activated by kallikrein/HMWK/anionic surface complex to

intitiate the intrinsic pathway

Molecular weight: 80,000 (2)

Extinction coefficient: E1 cm, 280 nm = 14.0

Isoelectric point: 6.8

Structure: single chain (Mr = 80,000), organized into 6 domains based

on sequence homology (5)

Percent carbohydrate: 17%

人因子Ⅻ HCXII-0155文獻參考：

1. Schmaier, A.H., et al., in Hemostasis ａnd Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and

E.W. Salzman, pp 18-38, J.B. Lippincott Company, Philadelphia, 1987.

2. Griffin, J.H. ａnd Cochrane, C.G., Methods Enzymol., 45, 56-65 (1976).

3. Saito, H., et al., J Lab Clin., 88, 506 (1976).

4. McMullen, B.A. ａnd Fujikawa, N., J. Biol. Chem., 260, 5328 (1985).

5. Davie, E.W., in Hemostasis ａnd Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder ａnd E.W.

Salzman, pp 242-267, J.B. Lippincott Company, Philadelphia, 1987.

6. Griffin, J.H., Proc. Natl. Acad. Sci. USA, 75, 1998 (1978).

7. McMillin, L.R., et al., J. Clin. Invest., 54, 1312 (1974).

8. Revak, S.D., et al., J. Clin. Invest., 59, 1167 (1977).

9. Fujikawa, K., et al., Biochemistry, 16, 4182 (1977).

10. Bonno, N., et al., in New Comprehensive Biochemistry, ed. R.F.A. Zwaal ａnd H.C.Hemker,

pp. 103-128, Elsevier, Amsterdam, 1986.

11. Claeys, H. ａnd Collen, D. (1978) Eur. J. Biochem., 87, 69 (1978).

12. Revak, S.D. ａnd Cochrane, C.G., J. Clin. Invest., 57, 852 (1976).

13. Cochrane, C.G., et al., J. Exp. Med., 138, 1564 (1973).

14. Revak, S.D., et al., J. Exp. Med., 147, 719 (1978).

15. Ghebrehiwet, B., et al., J. Clin. Invest., 71, 1458 (1983).

16. DeAgostini, A., et al., J. Clin. Invest., 73, 1542 (1984).

17. Rathoff, O.D., et al., J. Exp. Med., 129, 315 (1969).

18. Stead, N., et al., J. Biol Chem., 251, 6481 (1976).

19. Pixley, R.A., et al., J. Biol Chem., 260, 1723 (1985).

20. Gjonnass, H., Thromb. Diath. Haemorrh., 28, 182 (1972).

21. Radcliffe, R., et al., Blood, 59, 611 (1977).

來源：https://www.amyjet.com/products/HCXII-0155.shtml