艾美捷 LKT Labs 阿法替尼 基礎信息：

編號：A2077

cas：850140-72-6;439081-18-2

純度：≥98%

公式：C24H25ClFN5O3

配方重量：485.94

化學名稱：N-[4-[（3-氯-4-氟苯基）氨基]-7-[[（3S）-四氫-3-呋喃氧基]-6-喹唑啉基]-4（二甲氨基）-2-丁烯酰胺

IUPAC名稱：（2E）-N-4-[（3-氯-4-氟苯基）氨基]-7-[（3S）-四氫-3-呋喃氧基]-6-喹唑啉基}-4-（二甲氨基）-2-丁烯酰胺

同義詞：青苗 2992

熔點：130-142°C

外觀：淡黃色粉末

阿法替尼文獻參考：

Yap TA, Popat S. The role of afatinib in the management of non-small cell lung carcinoma. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1529-39. PMID: 23985030.

Janjigian YY, Viola-Villegas N, Holland JP, et al. Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG ａnd 89Zr-trastuzumab PET. J Nucl Med. 2013 Jun;54(6):936-43. PMID: 23578997.

Solca F, Dahl G, Zoephel A, et al. Target binding properties ａnd cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther. 2012 Nov;343(2):342-50. PMID: 22888144.

Hirsh V. Afatinib (BIBW 2992) development in non-small-cell lung cancer. Future Oncol. 2011 Jul;7(7):817-25. PMID: 21732753.

來源：https://www.amyjet.com/products/LKT-A2077-100mg.shtml