鏈親和素ZAP是鏈親和素和核糖體失活蛋白saporin的化學偶聯物。它將生物素化物質轉化為目標毒素。

Advanced Targeting Systems/ATSbio艾美捷這些試劑盒將生物素化物質轉化為靶向毒素，并允許用戶評估試劑與受體結合后內化的能力。

目標推薦      體內推薦     體外 

生物素化肽   鏈親和素ZAP肽試劑盒（KIT 27-B）  生物素Z肽內化試劑盒（KIT -27-ZB）

生物素化抗體  Streptavidin ZAP抗體試劑盒（KIT -27-A）山羊、人、小鼠、大鼠或兔生物素Z抗體內化試劑盒（KIT -27-Z）山羊、人、鼠、鼠或兔

其他生物素化材料 Streptavidin ZAP試劑盒（KIT 27-S）Streptavidin ZAPKIT（KIT-27-S）

Advanced Targeting Systems/ATSbio 艾美捷其它熱門ZAP研究：

IT-27 Streptavidin-ZAP 生物素化靶向劑

IT-51 Fab-ZAP human 人單克隆抗體

IT-48 Fab-ZAP mouse 小鼠單克隆抗體

IT-65 FabFc-ZAP human 人IgG

IT-55 Fab-ZAP rat 大鼠IgG

Advanced Targeting Systems/ATSbio艾美捷Streptavidin-ZAP相關文獻：

CD3e-immunotoxin spares CD62Llo Tregs ａnd reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells

Kim S, Shukla RK, Yu H, Baek A, Cressman SG, Golconda S, Lee GE, Choi H, Reneau JC, Wang Z, Huang CA, Liyanage NPM, Kim S (2022) CD3e-immunotoxin spares CD62Llo Tregs ａnd reshapes organ-specific T-cell composition by preferentially depleting CD3ehi T cells. Front Immunol 13:1011190. doi: 10.3389/fimmu.2022.1011190

Objective: To use a new murine testing model to demonstrate a substantial enrichment of tissue-resident Foxp3+ Tregs following CD3e-IT treatment.

Summary: The multi-organ pharmacodynamics of CD3e-IT ａnd potential treatment resistance mechanisms identified in this study may generate new opportunities to further improve this promising treatment.

Usage: Male C57BL/6J mice were injected into retro-orbital sinus with 15 μg S-CD3e-IT (Biotinylated Anti-CD3 mixed with Streptavidin-ZAP in sterile 200 μl PBS twice a day for four consecutive days.

Related Products: Streptavidin-ZAP (Cat. #IT-27)

In vivo visualization ａnd molecular targeting of the cardiac conduction system

Goodyer WR, Beyersdorf BM, Duan L, van den Berg NS, Mantri S, Galdos FX, Puluca N, Buikema JW, Lee S, Salmi D, Robinson ER, Rogalla S, Cogan DP, Khosla C, Rosenthal EL, Wu SM (2022) In vivo visualization ａnd molecular targeting of the cardiac conduction system. J Clin Invest e156955. doi: 10.1172/jci156955

Objective: To engineer targeted antibody conjugates directed against the cardiac conduction system (CCS) to allow visualization of the CCS in vivo.

Summary: Accidental injury to the CCS, a specialized set of cells embedded within the heart ａnd indistinguishable from the surrounding heart muscle tissue, is a major complication in cardiac surgeries. They generated a fully human monoclonal Fab (hCNTN2) that targets the CCS with high specificity.

Usage: Streptavidin-ZAP was reacted with biotinylated hCNTN2 Fab to create hCNTN2-SAP. 100 ug of either hCNTN2-SAP ａnd control-SAP were injected into wild-type mice with a single tail-vein injection ａnd hearts were harvested after 2 days.

Related Products: Streptavidin-ZAP (Cat. #IT-27)

Advanced Targeting Systems(ATSbio)主要研究域包含神經靶向毒素，神經生物學研究方面的抗體/蛋白，靶向劑內化水平檢測工具等。艾美捷科技是ATSbio的中國代理商，為科研工作者提供優質的產品與服務。

來源：https://www.amyjet.com/brand/Advanced-Targeting-Systems.shtml